Current models of operations and research involving clinical decision support (CDS) are too site-specific, not scalable, and do not measure translational outcomes. We propose to create a collaborative infrastructure centered around reusable CDS metrics that more effectively measures clinical outcomes and compares these benefits against the tradeoffs of alert burden and fatigue. Through our collaborative approach across ten CTSA Hubs, this study will be the first to use a translational science approach to understand the impact of CDS systems.